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So Gary, when we talk about mechanisms and we talk and how David relates it to low-carb diets, how do you see that fitting into the picture to say, yes, theyre basically another version of low-carb diets, or is there or more to it

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In line with NICE guidance, lower BMI thresholds may be appropriate for people from some ethnic groups

While prevention is paramount, this growing mechanistic framework raises hypotheses for future studies that targeting mitochondrial metabolism can open windows of epigenetic plasticity toward more positive health outcomes, particularly in subjects with a history of adverse childhood experiences